Manufacturing is not only the backbone of U.S. military-technical advantage, but also a major contributor to the U.S. economy. A healthy, innovative, and vibrant manufacturing sector is essential to the economic strength and national security of the United States. The Industrial IoT, coupled with 5G, security in IIoT, machine learning, and artificial intelligence, is impacting the future and growth of manufacturing. In this presentation, we will discuss and live demo how we use the zero trust model, machine learning, and 5G to design and implement a secure smart manufacturing testbed in a lab environment. The further discussion also includes how we collaborate with the manufacturing outreach center to engage local manufacturers and show business use cases that smart factories can drive value.